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Shihoko Kojima

Associate Professor of Biological Sciences
245D Steger Hall (MC 0477)
1015 Life Science Circle
Blacksburg, VA 24061

Major Field of Interest

Mammalian Circadian Biology

Current Research

Circadian rhythmicity is a fundamental aspect of temporal organization in essentially every cell in the body, and modulates much of physiology, biochemistry, and behavior.  In order to maintain daily cycles, cell-autonomous circadian oscillators drive rhythmic expression of approximately 5-10% of mRNAs to ultimately drive a wide range of rhythmic biological processes.

We are interested in understanding 1) how the circadian clock regulates the rhythms of thousands of mRNAs and proteins with the correct period, phase, and amplitude; and 2) how circadian clock utilizes rhythmically expressed proteins to regulate rhythmic physiology and behavior.  We use the mouse as an animal model system and integrate diverse approaches - genetics, genomics, bioinformatics, neuroscience, and molecular/cellular biology - to answer these questions.

  • 2015-2021 Assistant Professor, Department of Biological Sciences, Virginia Tech
  • 2009-2014 Instructor, Department of Neuroscience, UT Southwestern Medical Center
  • 2005-2009 Postdoctoral Fellow, Department of Biology, University of Virginia
  • 2003-2005 Postdoctoral Fellow, Institute of Medical Science, University of Tokyo, Institute of Life Science, Mitsubishi Kagaku
  • 2003 Ph. D. Health Sciences University of Tokyo
  • 2000 M. Pharm. Pharmaceutical Sciences Osaka University
  • 1998 B. Pharm. Pharmaceutical Sciences Osaka University
  • 2013 Japanese Society for Chronobiology, Young Investigator Award
  • 1999 The Japan Scholarship Foundation, Scholarship for Graduate Students