Shihoko Kojima

Assistant Professor of Biological Sciences

  • B.Pharm., Pharmaceutical Sciences, Osaka University, 1998
  • Ph.D., Human Genetics, University of Tokyo, 2003
  • Postdoctoral Fellow, Mitsubishi Kagaku, Institute of Life Science, 2003-2005
  • Postdoctoral Fellow, University of Virginia, 2005-2009
  • Instructor, UT Southwestern Medical Center, 2009-2014


The Kojima Laboratory Website


Major Field of Interest

Mammalian Circadian Biology

Current Research

Circadian rhythmicity is a fundamental aspect of temporal organization in essentially every cell in the body, and modulates much of physiology, biochemistry, and behavior.  In order to maintain daily cycles, cell-autonomous circadian oscillators drive rhythmic expression of approximately 5-10% of mRNAs to ultimately drive a wide range of rhythmic biological processes.

We are interested in understanding 1) how the circadian clock regulates the rhythms of thousands of mRNAs and proteins with the correct period, phase, and amplitude; and 2) how circadian clock utilizes rhythmically expressed proteins to regulate rhythmic physiology and behavior.  We use the mouse as an animal model system and integrate diverse approaches - genetics, genomics, bioinformatics, neuroscience, and molecular/cellular biology - to answer these questions.

  • (540) 231-5196
  • 162-B Biocomplexity Institute
    1015 Life Science Circle (MC 0477)
    Blacksburg, VA
  • Lab: (540) 231-9539