The Melville Lab Website


Major Field of Interest

Bacterial Pathogenesis

Current Research

  1. The interactions of the host immune system with the anaerobic bacterial pathogen Clostridium perfringens.  Specifically, the molecular mechanisms that allow the bacteria to avoid being killed by phagocytic cells of the immune system, macrophages and neutrophils
  2. The molecular regulation of toxin synthesis by C. perfringens, especially the enterotoxin that is responsible from food poisoning outbreaks
  3. The mechanism of pili-dependent gliding motility in C. perfringens