David Popham

Professor of Biological Sciences

  • Ph.D., Microbiology, University of California at Davis, 1989
  • Postdoctoral Fellow, Institut de Biologie Physico-Chimique, Paris, France, 1989 - 1991
  • Postdoctoral Fellow, University of Connecticut Health Center, 1991 - 1996


The Popham Lab Website


Major Field of Interest

Molecular Microbiology

Current Research

Structure, synthesis, and hydrolysis of the peptidoglycan wall components of vegetative cells and endospores.  Studies utilize the model Gram-positive bacterium Bacillus subtilis and the pathogens Bacillus anthracis and Clostridium difficile.  Molecular genetic techniques are used to identify and manipulate the genes encoding the enzymes that polymerize and hydrolyze the peptidoglycan.  Biochemical methods are used to examine the activities of these proteins and the peptidoglycan structural alterations associated with genetic and phenotypic changes.  Potential applications of this research are in antibiotic design and in spore-killing for decontamination procedures.

  • (540) 231-2529
  • dpopham@vt.edu
  • 207 Life Sciences I Building (MC 0910)
    970 Washington Street NW
    Blacksburg, VA 24061